Shark Liver Oil & Asthma

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     In order to understand the influences of shark liver oil on the cell, one must first understand the disease process itself.

     Asthma /Bronchial Asthma is a disease process that results from the increased responsiveness of the large breathing airway and small airways (in the lungs) to various stimuli. The effect seen is a cyclic narrowing of these airways with the production of a whistling sound called wheezing. The narrowing of the airway and its increased responsiveness to stimuli is thought to be due to inflammation. Stimuli may come in the form of allergens (dust, pollen, animals, foods, perfumes), viruses, (less often bacteria), some drugs, occupational hazards (fumes, gases, chemicals), weather changes.

     When the stimulus becomes present, a series of complex reactions take place to release a number of chemicals from different cells in the body (example mast cells) which then act on each other and other cells to produce the ‘inflammation’ and subsequently an asthma attack.

     Stimulus attaches to some cell membranes (mast cells) and through a series of interactions with chemicals (like diacylglycerols, protein kinase C and phospholipids and others) makes the membrane burst and release smaller chemicals that produce inflammation. The membrane of this mast cell is also transformed into another chemical-Arachidonic acid that is broken down even further to produce smaller chemicals that would produce even more inflammation.  In the meantime, the body activates other cells called macrophages which go around trying to find the stimulus to eat them in order to get rid of them.

      The active ingredient in Shark Liver Oil is Alkoxyglycerol and is found naturally in most plant and animal species including man. Study of this natural product reveals that it acts as both an immunostimulant (to boost the immune system) and also as an immunomodulator (helping the cells to function normally within the system). It is found in all tissues and all organs in the body (including mother’s milk) and has different functions depending on which organ system or tissues it is found in.

     Alkoxyglycerol therefore is multifunctional within the body. Hence, we will limit our discussion to just the cells that are pertinent to asthma (that I have mentioned above) and its effect on those cells.

Alkoxyglycerols (AKGs)–

1. Activates/energizes macrophages to eat the bad stimulus
2. Stops Protein Kinase C from releasing the small chemicals that would produce inflammation
3. Stop phospholipids and diacylglycerol transformation into arachidonic acid. Incidentally this is also where steroids work in helping to resolve the attack.
4. Because of its immunomodulation capabilities- it is thought that it helps with other cells called B cells and T cells to eventually help in stopping the cells from reacting to those stimuli in the future.

     So you can see where having extra AKGs in the form of shark liver oil on board will allow the body to be prepared for any attack and take care of the stimulus before it even launches its attack.

     Of course as we speak, much more research is ongoing as to the nature of the interaction between AKGs and the number of diseases that we are now finding that it has helped with. The first researchers in the 1920’s initially studied AKGs for their effects in cancer and leukemias. The studies in inflammatory and autoimmune diseases are now being done along with continuing ones on cancer. Who knows if they may find that the cause of a lot of diseases is related to a deficiency of AKGs in the human body.